Scientists say they have found probable cause that a substantial part of infertility in men in the world - without sperm protein levels and allows them to eggs. The protein acts as DEFB126; Klingon cloaking device, allowing the sperm to swim through the mucus and the immune system to keep out of reach of eggs, said Gary Cherri, a professor at the Center for Bodega Marine Laboratory UC Davis, Health and Environment . Cherri and the author of the article. But researchers at UC Davis has found that many men carry the defective gene for DEFB126. The examination of samples from the United States, Britain and China have shown that over a quarter of men around the world, two copies of the defective gene - can significantly affect fertility.
Infertility affects 10 to 15 percent of the U. S. population, said John Gould, associate professor of urology at UC Davis, who was not involved in the research. About half of those cases involve problems with male fertility.
One of the mysteries of human fertility is that sperm quality and quantity seem to have little do with whether or not a man is fertile, said Ted Tollner, first author of the paper, who carried out the work as a postdoctoral scholar with Cherr. Tollner is now an adjunct assistant professor in the UC Davis Department of Obstetrics and Gynecology.
"In 70 percent of men, you can''t explain their infertility on the basis of sperm count and quality," Cherr said. Studies like this may give us opportunities to explain these cases, Gould said.
If the discovery is successfully developed into a test, it could be used to send couples directly to treatment with intracytoplasmic sperm injection or ICSI, in which eggs are removed from the woman and injected directly with sperm, avoiding an expensive workup to exclude other causes, Gould said.
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